Main Article Content
Abstract
BACKGROUND
In this study, we wanted to evaluate to find the significant changes in count of platelets which are one of the blood components with advancing age both in males and females of 30 - 60 years’ age group, to study and analyze the count of platelets in three different age groups of males, to study and analyze the count of platelets in three different age groups of females, to compare the count of platelets in between males and females in different age groups.
METHODS
This was a hospital based analytical observational cross-sectional study conducted among patients in the 30-60 years’ age group in the Department of Physiology in collaboration with Department of Pathology and Department of General Medicine at Government Medical College, Srikakulam, Andhra Pradesh, India, after obtaining clearance from institutional ethics committee and written informed consent from the study participants.
RESULTS
Platelet count decreased with increase in age in males from 31-40 years’ age group to 41-50 years’ age group, and count slightly increased with increase in age from 41-50 years’ age group to 51-60 years’ age group in males. But in female’s platelet count increased with increase in age.
CONCLUSIONS
The present study was done in limited specific age groups that is in between 30-60 years. Further large studies should be done in large population different age groups to know the cause of age specific variations in platelets.
Keywords
Article Details

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References
- Fauci A, Braunwald E, Kasper D, et al. Harrison’s principles of internal medicine. 17th edn. McGraw Hill 2008:53-62.
- Toryila JE, Amada K, Adelaide AB. Platelet counts and mean platelet volume amongst elderly Nigerians. Science World Journal 2009;4(1):15-8.
- Kubota K, Shirakura T, Orui T, et al. Change in the Blood Cell Counts with Age. Japanese Journal of American Geriatrics Society 1991;28(4):509-14.
- Biino G, Balduini CL, Casula L, et al. Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits. Haematologica 2011;96(1):96-101.
- Dey D. Haematological reference ranges for adults in eastern India, Ashok laboratory centre for transfusion medicine and clinical research 2006. [Internet]. Available from: http://www.authorstream.com/Presentation/diganta_de y2006- 13821161-haematological-reference-ranges-for-adults-in-eastern-india/
- Balasubramaniam U, pandeya P, Sairam S, et al. Hematological and biochemical values in Indian Population. A Research Initiative of the Apollo Hospital Educational and Research Foundation (AHERF) 2008.
- Bovill EG, Bild DE, Heiss G, et al. White blood cell counts in persons aged 65 years or more from the cardiovascular health study. Amercican Journal of Epidemiology 1996;143(11):1107-15.
- Shirakura T, Murai Y, Takeda T, et al. Changes of Peripheral Blood Figures and Erythropoiesis in the Aged. Japanese Journal of American Geriatrics Society 1978;15(2):151-7.
- Faira AVS, Andrade SS, Maikel P, et al. Platelets in aging and cancer – ‘double – edged sword’. Cancer Metastasis Rev 2020;39:1205-21.
- Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990;323(1):1-6.
- Baldwin JG. True anaemia: incidence and significance in the elderly. Geriatrics 1989;44(8):33-6.
- Mahlknecht U, Kaiser S. Age-related changes in peripheral blood counts in humans. Exp Ther Med 2010;1(6):1019-25.
- Shaheen NA, Rehan H, Moghairi A, et al. Hematological indices in the adult Saudi population: Reference intervals by gender, age and region. Front Med (Lausanne) 2022;9:901937.
- Adeli K, Raizman JE, Chen Y, et al. Complex biological profile of hematologic markers across pediatric, adult and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian health measures survey. Clin Chem 2015;61(8):1075-86.
- Valiathan R, Ashman M, Asthana D. Effects of ageing on the immune system: infants to elderly. Scand J Immunol 2016;83(4):255-66.
- Padiala MS, Trivedi RS, Karmur K, et al. Effect of aging on WBC count and Platelet count. J Res Med Den Sci 2014;2(4):67-70.
- Snoeck HW. Aging of the hematopoietic system. Curr Opin Hematol 2013;20(4):355-61.
- Espinosa-Parrilla Y, Gonzalez-Billault C, Fuentes E, et al. Decoding the role of platelets and related micrornas in aging and neurodegenerative disorders. Front Aging Neurosci 2019;11:151.
- Calcinotto A, Kohli J, Zagato E, et al. Cellular senescence: aging, cancer and injury. Physiol Rev 2019;99(2):1047-8.
- Sparrow RL. Red blood cell components: time to revisit the sources of variability. Blood Transfus 2017;15(2):116.
- Hadjesfandiari N, Khorshidfar M, Devine DV. Current understanding of the relationship between blood donor variability and blood componrent quality. Int J Mol Sci 2021;22(8):3943.
- Farley A, Hendry C, McLafferty E. Blood components. Nurs Stand 2012;27(13):35-42.
- Elzen WPJ, Gussekloo J. Anaemia in older persons. 2011;69(6):260-7. Retrieved from https://hdl.handle.net/1887/117602.
- George-Gay B, Parker K. Understanding the complete blood count with differential. Journal of PeriAnesthesia Nursing 2003;18(2):96-117.
- McMahon BJ, Kwaan HC. Thrombocytopenia in older adults. Seminars in Thrombosis and Hemostasis 2014;40(6):682-7.
- Doig K. The rationale for a methodical approach to interpreting the complete blood count and its development. American Society for Clinical Laboratory Science 2017;30(3):171-2.
- Dixit S, Jha T, Gupta R, et al. Practical approach to the interpretation of complete blood count reports and histograms. Indian Pediatrics 2022;59(6):485-91.
- Maya GC. Interpretation of automated complete blood count: keys to a better application of the test. Medicinia and Laboratorio 2020;19(1-2):11-68.
- Almaliki M, Atlam E. Complete blood analysis: an android OCR-based interpretation. In intelligent computing: proceedings of the 2022 computing conference, Vol. 2. Cham: Springer International Publishing 2022 :278-93.
- Cavalieri TA, Chopra A, Bryman PN. When outside the norm is normal: interpreting lab data in the aged. Geriatrics 1992;47(5):66-70.
- Doig K, Butina M. A methodical approach to interpreting the platelet parameters of the complete blood count. American Society for Clinical Laboratory Science 2017;30(3):194-201.
- Jameel T, Baig M, Albejad MI, et al. Medical students’ understanding and interpreting abilities for Complete Blood Counts (CBC) in clinical practice. Middle East Journal of Family Medicine 2022;7(10):35.
- Thomas EA, Bhagya S, Majeed A. Clinical utility of blood cell histogram interpretation. Journal of Clinical and Diagnostic Research: JCDR 2017;11(9):OE01.
- Haywood M. Interpreting the full blood count. InnovAiT 2022;15(3):131-7.
- Tillati S, Pati I, Donne MD, et al. Horiba Micros ES 60 blood cell analyzer in blood donor eligibility: a validation study. Diagnostics 2022;12(11):2586.
- Gallerani M, Reverberi R, Salmi R, et al. Seasonal variation of platelets in a cohort of Italian blood donors: a preliminary report. Eur J Med Res 2013;18(1):31.
- Biino G, Santimone I, Minelli C, et al. Age and sex related variations in platelet count in Italy: A proposal of reference ranges based on 40987 subjects’ data. PLoS One 2013;8(1):e54289.
- Butkiewicz AM, Kemona H, Dymicka-Piekarsha V, et al. Platelet count, mean platelet count and thrombocytopoietic indices in healthy women and men. Thromb Res 2006;118(2):199-204.
References
Fauci A, Braunwald E, Kasper D, et al. Harrison’s principles of internal medicine. 17th edn. McGraw Hill 2008:53-62.
Toryila JE, Amada K, Adelaide AB. Platelet counts and mean platelet volume amongst elderly Nigerians. Science World Journal 2009;4(1):15-8.
Kubota K, Shirakura T, Orui T, et al. Change in the Blood Cell Counts with Age. Japanese Journal of American Geriatrics Society 1991;28(4):509-14.
Biino G, Balduini CL, Casula L, et al. Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits. Haematologica 2011;96(1):96-101.
Dey D. Haematological reference ranges for adults in eastern India, Ashok laboratory centre for transfusion medicine and clinical research 2006. [Internet]. Available from: http://www.authorstream.com/Presentation/diganta_de y2006- 13821161-haematological-reference-ranges-for-adults-in-eastern-india/
Balasubramaniam U, pandeya P, Sairam S, et al. Hematological and biochemical values in Indian Population. A Research Initiative of the Apollo Hospital Educational and Research Foundation (AHERF) 2008.
Bovill EG, Bild DE, Heiss G, et al. White blood cell counts in persons aged 65 years or more from the cardiovascular health study. Amercican Journal of Epidemiology 1996;143(11):1107-15.
Shirakura T, Murai Y, Takeda T, et al. Changes of Peripheral Blood Figures and Erythropoiesis in the Aged. Japanese Journal of American Geriatrics Society 1978;15(2):151-7.
Faira AVS, Andrade SS, Maikel P, et al. Platelets in aging and cancer – ‘double – edged sword’. Cancer Metastasis Rev 2020;39:1205-21.
Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990;323(1):1-6.
Baldwin JG. True anaemia: incidence and significance in the elderly. Geriatrics 1989;44(8):33-6.
Mahlknecht U, Kaiser S. Age-related changes in peripheral blood counts in humans. Exp Ther Med 2010;1(6):1019-25.
Shaheen NA, Rehan H, Moghairi A, et al. Hematological indices in the adult Saudi population: Reference intervals by gender, age and region. Front Med (Lausanne) 2022;9:901937.
Adeli K, Raizman JE, Chen Y, et al. Complex biological profile of hematologic markers across pediatric, adult and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian health measures survey. Clin Chem 2015;61(8):1075-86.
Valiathan R, Ashman M, Asthana D. Effects of ageing on the immune system: infants to elderly. Scand J Immunol 2016;83(4):255-66.
Padiala MS, Trivedi RS, Karmur K, et al. Effect of aging on WBC count and Platelet count. J Res Med Den Sci 2014;2(4):67-70.
Snoeck HW. Aging of the hematopoietic system. Curr Opin Hematol 2013;20(4):355-61.
Espinosa-Parrilla Y, Gonzalez-Billault C, Fuentes E, et al. Decoding the role of platelets and related micrornas in aging and neurodegenerative disorders. Front Aging Neurosci 2019;11:151.
Calcinotto A, Kohli J, Zagato E, et al. Cellular senescence: aging, cancer and injury. Physiol Rev 2019;99(2):1047-8.
Sparrow RL. Red blood cell components: time to revisit the sources of variability. Blood Transfus 2017;15(2):116.
Hadjesfandiari N, Khorshidfar M, Devine DV. Current understanding of the relationship between blood donor variability and blood componrent quality. Int J Mol Sci 2021;22(8):3943.
Farley A, Hendry C, McLafferty E. Blood components. Nurs Stand 2012;27(13):35-42.
Elzen WPJ, Gussekloo J. Anaemia in older persons. 2011;69(6):260-7. Retrieved from https://hdl.handle.net/1887/117602.
George-Gay B, Parker K. Understanding the complete blood count with differential. Journal of PeriAnesthesia Nursing 2003;18(2):96-117.
McMahon BJ, Kwaan HC. Thrombocytopenia in older adults. Seminars in Thrombosis and Hemostasis 2014;40(6):682-7.
Doig K. The rationale for a methodical approach to interpreting the complete blood count and its development. American Society for Clinical Laboratory Science 2017;30(3):171-2.
Dixit S, Jha T, Gupta R, et al. Practical approach to the interpretation of complete blood count reports and histograms. Indian Pediatrics 2022;59(6):485-91.
Maya GC. Interpretation of automated complete blood count: keys to a better application of the test. Medicinia and Laboratorio 2020;19(1-2):11-68.
Almaliki M, Atlam E. Complete blood analysis: an android OCR-based interpretation. In intelligent computing: proceedings of the 2022 computing conference, Vol. 2. Cham: Springer International Publishing 2022 :278-93.
Cavalieri TA, Chopra A, Bryman PN. When outside the norm is normal: interpreting lab data in the aged. Geriatrics 1992;47(5):66-70.
Doig K, Butina M. A methodical approach to interpreting the platelet parameters of the complete blood count. American Society for Clinical Laboratory Science 2017;30(3):194-201.
Jameel T, Baig M, Albejad MI, et al. Medical students’ understanding and interpreting abilities for Complete Blood Counts (CBC) in clinical practice. Middle East Journal of Family Medicine 2022;7(10):35.
Thomas EA, Bhagya S, Majeed A. Clinical utility of blood cell histogram interpretation. Journal of Clinical and Diagnostic Research: JCDR 2017;11(9):OE01.
Haywood M. Interpreting the full blood count. InnovAiT 2022;15(3):131-7.
Tillati S, Pati I, Donne MD, et al. Horiba Micros ES 60 blood cell analyzer in blood donor eligibility: a validation study. Diagnostics 2022;12(11):2586.
Gallerani M, Reverberi R, Salmi R, et al. Seasonal variation of platelets in a cohort of Italian blood donors: a preliminary report. Eur J Med Res 2013;18(1):31.
Biino G, Santimone I, Minelli C, et al. Age and sex related variations in platelet count in Italy: A proposal of reference ranges based on 40987 subjects’ data. PLoS One 2013;8(1):e54289.
Butkiewicz AM, Kemona H, Dymicka-Piekarsha V, et al. Platelet count, mean platelet count and thrombocytopoietic indices in healthy women and men. Thromb Res 2006;118(2):199-204.