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Abstract
Atrial flutter is a supraventricular tachyarrhythmia. It is a rare and life-threatening condition during both the fetus and neonatal periods. In severe instances, atrial flutter can compromise circulation and may result in non-immune hydrops fetalis or even fetal demise. Management typically involves the use of antiarrhythmic drugs, transesophageal overdrive pacing, or synchronized direct current cardioversion. Nonetheless, when identified early and treated appropriately, the overall outlook is positive in the majority of cases.
Tachycardia in neonates is defined as a persistent increase in heart rate above 180 beats/min. The incidence of arrhythmias for neonatal period is about 1%.[1] Atrial flutter is an uncommon type of fetal and neonatal arrhythmia. Atrial flutter occurs in approximately 2.1 out of every 100,000 live births, with structural heart defects present in around 36% of these cases.[2] It constitutes about 32% (nearly one third) of all neonatal cardiac arrhythmias.[3] The mechanism of atrial flutter in the newborns remains unknown. This type of arrhythmia is often caused by re-entry circuits confined to the right atrium.[4] It is most commonly seen in children with congenital heart anomalies such as transposition of the great arteries, complex cyanotic heart disease, atrial septal defects, pulmonary stenosis, and abnormalities of the tricuspid valve. Atrial flutter may also arise following surgical procedures involving the atria, particularly after interventions like atrial switch operations for transposition of the great arteries or repair of Tetralogy of Fallot. Although it is relatively rare, atrial flutter can be life-threatening during the fetal and neonatal periods. The condition carries an estimated perinatal mortality rate of around 9%.[5]
We report a case of a newborn with atrial flutter in the Department of Paediatrics at TRIHMS Hospital, Arunachal Pradesh. The patient’s guardian was duly informed and consent was obtained for publication of case report for medical benefit.
We report a case of a term, large for gestational age neonate who was born via lower segment caesarean section with uneventful antenatal history. His heart rate was persistently between 195-205 beats per minute. An electrocardiogram was performed, which was suggestive of atrial flutter. The atrial flutter was resistant to amiodarone therapy. Synchronised cardioversion was performed and normal sinus rhythm was achieved.
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References
- Badrawi N, Hegazy RA, Tokovic E, et al. Arrhythmia in the neonatal intensive care unit. Pediatr Cardiol 2009;30:325-30.
- Turner CJ, Wren C. The epidemiology of arrhythmia in infants: a population based study. J Paediatr Child Health 2013;49:278-81.
- Southall DP, Johnson AM, Shinebourne EA, et al. Frequency and outcome of disorders of cardiac rhythm and conduction in a population of newborn infants. Pediatrics 1981;68:58-66.
- Shi-Min Y. Fetal arrhythmias: surveillance and management. Hellenic J Cardiol 2019;60:72-81.
- Kohl KT, Simpson JM, Sharland GK, et al. Review of diagnosis, treatment, and outcome of fetal atrial flutter compared with supraventricular tachycardia. Heart 2003;89(8):913-7.
- Wójtowicz-Marzec M, Wysokińska B, Respondek-Liberska M. Successful treatment of neonatal atrial flutter by synchronized cardioversion: case report and literature review. BMC Pediatr 2020;20(1):370.
- James H. Moller JH, Davachi F, et al. Atrial flutter in infancy. J Pediatr 1999;75:643-51.
- Wren C. Cardiac arrhythmias in the fetus and newborn. Semin Fetal Neonatal Med 2006;11:182-90.
- Pike JI, Krishnan A, Kaltman J, et al. Fetal and neonatal atrial arrhythmias: an association with maternal diabetes and neonatal macrosomia. Prenat Diagn 2013;33:1152-7.
- Hassenruck A, Chojnacki B, Barker HJ. Cardioversion of auricular flutter in a new born infant. Am J Cardiol 1965;15:726–31.
- Maury P, Mansourati J, Fauchier L, et al. Management of sustained arrhythmias for patients with cardiogenic shock in intensive cardiac care units. Archives of Cardiovascular Diseases 2019;112(12):781-91.
- Maury P, Rollin A, Galinier M, et al. Role of digoxin in controlling the ventricular rate during atrial fibrillation: a systematic review and a rethinking. Research Reports in Clinical Cardiology 2014;5:93-101.
- Rennie J. Robertson’s textbook of neonatology. 5th edn. Churchill Livingstone 2012.
- Texter KM, Kertesz NJ, Friedman RA, et al. Atrial flutter in infants. J Am Coll Cardiol 2006;48:1040-6.
- Ceresnak SR, Starc TJ, Hordof AJ, et al. Elevated impedance during cardioversion in neonates with atrial flutter. Pediatr Cardiol 2009;30:436-40.
- Lisowski LA, Verheijen PM, Benatar AA, et al. Atrial flutter in the perinatal age group: diagnosis, management and outcome. J Am Coll Cardiol 2000;35:771-7.
- Knirsch W, Ketschmar O, Vogel M, et al. Successful treatment of atrial flutter with amiodarone in a premature neonate. Case report and literature review. Adv Neonatal Care 2007;7(3):113-21.
- Crochelet AS, Jacquemart C, Massin M. Repeated electrical cardioversions and amiodarone for recurrent neonatal atrial flutter. Arch Pediatr 2015;22(10):1032-4.
- Gandy J, Wonko N, Kantoch MJ. Risks of intravenous amiodarone in neonates. Can J Cardiol 1998;14(6):855-88.
- Burri S, Hug MI, Bauersfeld U. Efficacy and safety of intravenous amiodarone for incessant tachycardias in infants. Eur J Pediatr 2003;162(12):880-4.
- Kwok SY, Davis AM, Hutchinson D, et al. Successful ablation of refractory neonatal atrial flutter. Heart Rhythm Case Rep 2015;1(4):245-8.
- Abdulla R. Current concepts in diagnosis and management of arrhythmias in infants and children. Pediatr Cardiol 1998;19:351.
- Marzbanrad F, Stroux L, Clifford GD. Cardiotocography and beyond: a review of one-dimensional Doppler ultrasound application in fetal monitoring. Physiol Meas 2018;39(8):08TR01.
- Aarti S, George F. Supraventricular tachycardia. In: Kleigman RM, Behrman RE, Blum NJ, et al, eds. Nelson Text book of pediatrics. 21st edn. Elsevier 2020: p. 2439.
- Casey FA, McCrindle BW, Hamilton RM, et al. Neonatal atrial flutter: significant early morbidity and excellent long term prognosis. Am Heart J 1997;133(3):302-6.
References
Badrawi N, Hegazy RA, Tokovic E, et al. Arrhythmia in the neonatal intensive care unit. Pediatr Cardiol 2009;30:325-30.
Turner CJ, Wren C. The epidemiology of arrhythmia in infants: a population based study. J Paediatr Child Health 2013;49:278-81.
Southall DP, Johnson AM, Shinebourne EA, et al. Frequency and outcome of disorders of cardiac rhythm and conduction in a population of newborn infants. Pediatrics 1981;68:58-66.
Shi-Min Y. Fetal arrhythmias: surveillance and management. Hellenic J Cardiol 2019;60:72-81.
Kohl KT, Simpson JM, Sharland GK, et al. Review of diagnosis, treatment, and outcome of fetal atrial flutter compared with supraventricular tachycardia. Heart 2003;89(8):913-7.
Wójtowicz-Marzec M, Wysokińska B, Respondek-Liberska M. Successful treatment of neonatal atrial flutter by synchronized cardioversion: case report and literature review. BMC Pediatr 2020;20(1):370.
James H. Moller JH, Davachi F, et al. Atrial flutter in infancy. J Pediatr 1999;75:643-51.
Wren C. Cardiac arrhythmias in the fetus and newborn. Semin Fetal Neonatal Med 2006;11:182-90.
Pike JI, Krishnan A, Kaltman J, et al. Fetal and neonatal atrial arrhythmias: an association with maternal diabetes and neonatal macrosomia. Prenat Diagn 2013;33:1152-7.
Hassenruck A, Chojnacki B, Barker HJ. Cardioversion of auricular flutter in a new born infant. Am J Cardiol 1965;15:726–31.
Maury P, Mansourati J, Fauchier L, et al. Management of sustained arrhythmias for patients with cardiogenic shock in intensive cardiac care units. Archives of Cardiovascular Diseases 2019;112(12):781-91.
Maury P, Rollin A, Galinier M, et al. Role of digoxin in controlling the ventricular rate during atrial fibrillation: a systematic review and a rethinking. Research Reports in Clinical Cardiology 2014;5:93-101.
Rennie J. Robertson’s textbook of neonatology. 5th edn. Churchill Livingstone 2012.
Texter KM, Kertesz NJ, Friedman RA, et al. Atrial flutter in infants. J Am Coll Cardiol 2006;48:1040-6.
Ceresnak SR, Starc TJ, Hordof AJ, et al. Elevated impedance during cardioversion in neonates with atrial flutter. Pediatr Cardiol 2009;30:436-40.
Lisowski LA, Verheijen PM, Benatar AA, et al. Atrial flutter in the perinatal age group: diagnosis, management and outcome. J Am Coll Cardiol 2000;35:771-7.
Knirsch W, Ketschmar O, Vogel M, et al. Successful treatment of atrial flutter with amiodarone in a premature neonate. Case report and literature review. Adv Neonatal Care 2007;7(3):113-21.
Crochelet AS, Jacquemart C, Massin M. Repeated electrical cardioversions and amiodarone for recurrent neonatal atrial flutter. Arch Pediatr 2015;22(10):1032-4.
Gandy J, Wonko N, Kantoch MJ. Risks of intravenous amiodarone in neonates. Can J Cardiol 1998;14(6):855-88.
Burri S, Hug MI, Bauersfeld U. Efficacy and safety of intravenous amiodarone for incessant tachycardias in infants. Eur J Pediatr 2003;162(12):880-4.
Kwok SY, Davis AM, Hutchinson D, et al. Successful ablation of refractory neonatal atrial flutter. Heart Rhythm Case Rep 2015;1(4):245-8.
Abdulla R. Current concepts in diagnosis and management of arrhythmias in infants and children. Pediatr Cardiol 1998;19:351.
Marzbanrad F, Stroux L, Clifford GD. Cardiotocography and beyond: a review of one-dimensional Doppler ultrasound application in fetal monitoring. Physiol Meas 2018;39(8):08TR01.
Aarti S, George F. Supraventricular tachycardia. In: Kleigman RM, Behrman RE, Blum NJ, et al, eds. Nelson Text book of pediatrics. 21st edn. Elsevier 2020: p. 2439.
Casey FA, McCrindle BW, Hamilton RM, et al. Neonatal atrial flutter: significant early morbidity and excellent long term prognosis. Am Heart J 1997;133(3):302-6.