Main Article Content
Abstract
LEC (Lymphoepithelial Carcinoma) arising in the salivary glands is extremely rare; it was originally described by Hilderman in 1962 and comprises only 0.4% of salivary carcinomas.[1,2] It is identified by histopathological features of undifferentiated malignant epithelial cells within lymphoid stroma cells.[3] It has a female preponderance. It is associated with Epstein-Barr virus infection; the Arctic Inuit, Japanese, and Southern Chinese populations have a strong association with EBV infection.[4] The histology is closely related to nasopharyngeal carcinoma; hence, it has to be ruled out. Commonly found in foregut derivatives, salivary glands, thymus, stomach and liver. However, other anatomical locations, such as the bladder, lacrimal glands, ovaries, cervix, and skin, were also reported.[5] The mainstay of treatment of parotid LEC is surgical resection with adequate safety margins for patients with resectable tumours.[2] LEC is highly radiosensitive; hence, surgery with adjuvant radiotherapy improves the patients' long-term survival compared to those treated with surgery alone. We present this rare case of primary lymphoepithelial carcinoma of the left parotid gland, which was treated with superficial parotidectomy followed by adjuvant radiotherapy.
Our case report describes an 85-year-old female diagnosed with primary lymphoepithelial carcinoma of the left parotid, treated with left superficial parotidectomy with adjuvant radiotherapy. There were no recurrences noted during one year of follow-up; currently, the patient is under regular follow-up.
We present this rare case of primary lymphoepithelial carcinoma of the left parotid gland, which was treated with superficial parotidectomy followed by adjuvant radiotherapy.
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
- Hilderman WC, Gordon JS, Large HJ, et al. Malignant lymphoepithelial lesion with carcinomatous component apparently arising in parotid gland. A malignant counterpart of benign lymphoepithelial lesion? Cancer 1962;15:606-10.
- Thompson LDR, Whaley RD. Lymphoepithelial carcinoma of salivary glands. Surg Pathol Clin 2021;14(1):75 96.
- Venkatasamy R, Ramasamy V, Rahim S, et al. Uncommon sites of lymphoepithelial carcinoma in head and neck region. Cureus 2023;15(3):e36694.
- Seethala R, Thompson LDR, Wenig M, et al Lymphoepithelial Carcinoma. In: Skalova A, Hyrcza MD, Mehrotra R, eds. WHO Classification of Head and Neck Tumours. 5thedn. Lyon: IARC Press 2022.
- Wong JF, Teo MC. Case report: lymphoepithelial-like carcinoma of the lung-a chronic disease? World J Surg Onc2012;10:91.
- Barnes L, Everson JW, Reichart P. Lymphoepithelial carcinoma. World Health Organization classification of tumours. In: Sidransky D, ed. Pathology and genetics of head and neck tumors. IARC Press 2005:251-2.
- Kott ET, Goepfert H, Ayala AG, et al. Lymphoepithelial carcinoma (malignant lymphoepithelial lesion) of the salivary glands. Arch Otolaryngol 1984;110:50-3.
- Christe A, Waldherr C, Hallett R, et al. MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. Am J Neuroradiol 2011;32(7):1202-7.
- Dong Y, Lei GW, Wang SW, et al. Diagnostic value of CT perfusion imaging for parotid neoplasms. Dentomaxillofac Radiol 2014;43(1):20130237.
- Hipp JA, Jing X, Zarka MA, et al Cytomorphologic characteristics and differential diagnoses of lymphoepithelial carcinoma of the parotid. J Am Soc Cytopathol2016;5:93 9.
- Kim YJ, Hong HS, Jeong SH, et al Lymphoepithelial carcinoma of the salivary glands. Medicine (Baltimore) 2017;96:e6115.
- Zhan KY, Nicolli EA, Khaja SF,et al Lymphoepithelial carcinoma of the major salivary glands: predictors of survival in a non endemic region. Oral Oncol 2016;52:24-9.
- Deng DF, Zhou Q, Ye ZM, et al. Clinical analysis of 12 patients with primary lymphoepithelial carcinoma of the parotid gland. Eur Arch Otorhinolaryngol 2022;279:2003-8.
- Airoldi M, Gabriele AM, Gabriele P, et al. Concomitant chemoradiotherapy followed by adjuvant chemotherapy in parotid gland undifferentiated carcinoma. Tumori 2001;87(1):14-7.
- Wang JQ, Deng RX, Liu H, et al. Clinicopathological characteristics and prognostic analysis of lymphoepithelial carcinoma of salivary gland: a population based study. Gland Surg 2020;9(6):1989–97.
- Ma H, Lin Y, Wang L, et al. Primary lymphoepithelioma- like carcinoma of salivary gland: sixty-nine cases with long- term follow-up. Head Neck 2014;36(9):1305-12.
References
Hilderman WC, Gordon JS, Large HJ, et al. Malignant lymphoepithelial lesion with carcinomatous component apparently arising in parotid gland. A malignant counterpart of benign lymphoepithelial lesion? Cancer 1962;15:606-10.
Thompson LDR, Whaley RD. Lymphoepithelial carcinoma of salivary glands. Surg Pathol Clin 2021;14(1):75 96.
Venkatasamy R, Ramasamy V, Rahim S, et al. Uncommon sites of lymphoepithelial carcinoma in head and neck region. Cureus 2023;15(3):e36694.
Seethala R, Thompson LDR, Wenig M, et al Lymphoepithelial Carcinoma. In: Skalova A, Hyrcza MD, Mehrotra R, eds. WHO Classification of Head and Neck Tumours. 5thedn. Lyon: IARC Press 2022.
Wong JF, Teo MC. Case report: lymphoepithelial-like carcinoma of the lung-a chronic disease? World J Surg Onc2012;10:91.
Barnes L, Everson JW, Reichart P. Lymphoepithelial carcinoma. World Health Organization classification of tumours. In: Sidransky D, ed. Pathology and genetics of head and neck tumors. IARC Press 2005:251-2.
Kott ET, Goepfert H, Ayala AG, et al. Lymphoepithelial carcinoma (malignant lymphoepithelial lesion) of the salivary glands. Arch Otolaryngol 1984;110:50-3.
Christe A, Waldherr C, Hallett R, et al. MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. Am J Neuroradiol 2011;32(7):1202-7.
Dong Y, Lei GW, Wang SW, et al. Diagnostic value of CT perfusion imaging for parotid neoplasms. Dentomaxillofac Radiol 2014;43(1):20130237.
Hipp JA, Jing X, Zarka MA, et al Cytomorphologic characteristics and differential diagnoses of lymphoepithelial carcinoma of the parotid. J Am Soc Cytopathol2016;5:93 9.
Kim YJ, Hong HS, Jeong SH, et al Lymphoepithelial carcinoma of the salivary glands. Medicine (Baltimore) 2017;96:e6115.
Zhan KY, Nicolli EA, Khaja SF,et al Lymphoepithelial carcinoma of the major salivary glands: predictors of survival in a non endemic region. Oral Oncol 2016;52:24-9.
Deng DF, Zhou Q, Ye ZM, et al. Clinical analysis of 12 patients with primary lymphoepithelial carcinoma of the parotid gland. Eur Arch Otorhinolaryngol 2022;279:2003-8.
Airoldi M, Gabriele AM, Gabriele P, et al. Concomitant chemoradiotherapy followed by adjuvant chemotherapy in parotid gland undifferentiated carcinoma. Tumori 2001;87(1):14-7.
Wang JQ, Deng RX, Liu H, et al. Clinicopathological characteristics and prognostic analysis of lymphoepithelial carcinoma of salivary gland: a population based study. Gland Surg 2020;9(6):1989–97.
Ma H, Lin Y, Wang L, et al. Primary lymphoepithelioma- like carcinoma of salivary gland: sixty-nine cases with long- term follow-up. Head Neck 2014;36(9):1305-12.