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Abstract
Sebaceous carcinoma of the eyelid is an aggressive neoplasm of the ocular adnexa. It is considered the third most common eyelid malignancy after basal cell carcinoma and squamous cell carcinoma. It occurs commonly in the elderly with a high incidence of recurrence and metastases. It can be mistaken for chalazion, a benign inflammatory condition. These lesions have a tendency for pagetoid spread within the conjunctival epithelium or the overlying skin.
We report a case of recurrent upper eyelid sebaceous carcinoma in 45-year-old female. Sebaceous gland carcinoma (SGC) is a rare, aggressive malignant tumor arising from the sebaceous glands of the eyelid, most commonly the meibomian glands of the upper eyelid. It accounts for a higher proportion of eyelid malignancies in Asian populations compared with Western countries and is characterized by a high risk of local recurrence, regional lymph node metastasis, and mortality if diagnosis is delayed. Recurrent sebaceous gland carcinoma presents additional therapeutic challenges because of its infiltrative growth pattern and the increased risk of orbital extension and distant spread.
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References
- Kass L, Hornblass A. Sebaceous carcinoma of the ocular adnexa. Surv Ophthalmol 1989;33:477-90.
- Shields J, Demirci H, Marr B. Sebaceous carcinoma of the ocular region: a review. Surv Ophthalmol 2005;50:103-22.
- Cicinelli M, Kaliki S, Ocular sebaceous gland carcinoma: an update of the literature. Int Ophthalmol 2019;39(5):1187-97.
- Kaliki S, Ayyar A, Dave TV. Sebaceous gland carcinoma of the eyelid: Clinicopathological features and outcome in Asian Indians. Eye (London, England) 2015;29(7):958-63.
- Shields JA, Demirci H, Marr BP, Sebaceous carcinoma of the eyelids: personal experience with 60 cases. Ophthalmology 2004;111(12):2151-7.
- Wali U, Al-Mujaini A, Sebaceous gland carcinoma of the eyelid. Oman J Ophthalmol 2010;3(3):117-21.
- Rashid A, Jakobiec FA, Avoiding the major complication of ophthalmic pathology: misdiagnosis. A review of three common diagnostic challenges. Semin Ophthalmol 2014;29(5–6):468-74.
- Jakobiec F, Mendoza P. Eyelid sebaceous carcinoma: Clinicopathologic and multiparametric immunohistochemical analysis that includes adipophilin. Am J Ophthalmol 2014;157(1):186-208.
- Prieto-Granada C, Rodriguez-Waitkus P. Sebaceous carcinoma of the eyelid. Cancer Control 2016;23(2):126-32.
- Snow SN, Larson PO, Lucarelli MJ. Sebaceous carcinoma of the eyelids treated by mohs micrographic surgery: report of nine cases with review of the literature. Dermatol Surg 2002;28:623-31.
- Dasgupta T, Wilson L, Yu J. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer 2015;115:158-65.
- Husain A, Blumenschein G, Esmaeli B. Treatment and outcomes for metastatic sebaceous cell carcinoma of the eyelid: Int J Dermatol 2008;47:276-9.
- Muqit M, Roberts F, Lee W, et al. Improved survival rates in sebaceous carcinoma of the eyelid. Eye (Lond) 2004;19(1):49-53.
References
Kass L, Hornblass A. Sebaceous carcinoma of the ocular adnexa. Surv Ophthalmol 1989;33:477-90.
Shields J, Demirci H, Marr B. Sebaceous carcinoma of the ocular region: a review. Surv Ophthalmol 2005;50:103-22.
Cicinelli M, Kaliki S, Ocular sebaceous gland carcinoma: an update of the literature. Int Ophthalmol 2019;39(5):1187-97.
Kaliki S, Ayyar A, Dave TV. Sebaceous gland carcinoma of the eyelid: Clinicopathological features and outcome in Asian Indians. Eye (London, England) 2015;29(7):958-63.
Shields JA, Demirci H, Marr BP, Sebaceous carcinoma of the eyelids: personal experience with 60 cases. Ophthalmology 2004;111(12):2151-7.
Wali U, Al-Mujaini A, Sebaceous gland carcinoma of the eyelid. Oman J Ophthalmol 2010;3(3):117-21.
Rashid A, Jakobiec FA, Avoiding the major complication of ophthalmic pathology: misdiagnosis. A review of three common diagnostic challenges. Semin Ophthalmol 2014;29(5–6):468-74.
Jakobiec F, Mendoza P. Eyelid sebaceous carcinoma: Clinicopathologic and multiparametric immunohistochemical analysis that includes adipophilin. Am J Ophthalmol 2014;157(1):186-208.
Prieto-Granada C, Rodriguez-Waitkus P. Sebaceous carcinoma of the eyelid. Cancer Control 2016;23(2):126-32.
Snow SN, Larson PO, Lucarelli MJ. Sebaceous carcinoma of the eyelids treated by mohs micrographic surgery: report of nine cases with review of the literature. Dermatol Surg 2002;28:623-31.
Dasgupta T, Wilson L, Yu J. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer 2015;115:158-65.
Husain A, Blumenschein G, Esmaeli B. Treatment and outcomes for metastatic sebaceous cell carcinoma of the eyelid: Int J Dermatol 2008;47:276-9.
Muqit M, Roberts F, Lee W, et al. Improved survival rates in sebaceous carcinoma of the eyelid. Eye (Lond) 2004;19(1):49-53.