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Abstract
Neurofibromas are benign nerve sheath tumors arising from Schwann cells and fibroblasts. They are commonly associated with NF1 (Neurofibromatosis Type 1) a genetic disorder with a birth incidence of about 1 in 3000 individuals. Chest wall neurofibroma is a relatively rare benign tumor, with a low incidence compared to other chest tumors. The specific incidence rate for anterior chest wall neurofibromas is not explicitly detailed in the search results; however, only a few cases have been reported.[1]
This report discusses a case of a large benign neurofibroma of the anterior chest wall in a 39-year-old male, highlighting its clinical presentation, radiological features, surgical approach, and histopathological findings.
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References
- Gutmann DH, Aylsworth A, Carey JC, et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 1997;278:51-7. DOI: https://doi.org/10.1001/jama.1997.03550010065042
- Ferner RE, Gutmann DH. Neurofibromatosis type 1 (NF1): diagnosis and management. Handb Clin Neurol 2015;132:193-214.
- Kransdorf MJ, Murphey MD. Imaging of soft tissue tumors. Lippincott Williams & Wilkins 2013.
- Rodriguez FJ, Folpe AL, Giannini C, et al. Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol 2012;123(3):295-319. DOI: https://doi.org/10.1007/s00401-012-0954-z
- Pilavaki M, Chourmouzi D, Kiziridou A, et al. Imaging of peripheral nerve sheath tumors with pathologic correlation: Pictorial review. Eur J Radiol 2004;52(3):229-39. DOI: https://doi.org/10.1016/j.ejrad.2003.12.001
- Wasa J, Nishida Y, Tsukushi S, et al. MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol 2010;194(6):1568-74. DOI: https://doi.org/10.2214/AJR.09.2724
- Weiss SW, Goldblum JR. Enzinger and Weiss’s soft tissue tumors. 6th edn. Elsevier 2013.
- Fletcher CDM, Bridge JA, Hogendoorn PCW, et al. WHO classification of tumours of soft tissue and bone. 4th edn. IARC Press 2013.
- Evans DG, Baser ME, McGaughran J, et al. Malignant peripheral nerve sheath tumors in neurofibromatosis 1. J Med Genet 2002;39(5):311-4. DOI: https://doi.org/10.1136/jmg.39.5.311
- Hruban RH, Shiu MH, Senie RT, et al. Malignant peripheral nerve sheath tumors of the buttock and lower extremity: a study of 43 cases. Cancer 1990;66(6):1253-65. DOI: https://doi.org/10.1002/1097-0142(19900915)66:6<1253::AID-CNCR2820660627>3.0.CO;2-R
References
Gutmann DH, Aylsworth A, Carey JC, et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 1997;278:51-7. DOI: https://doi.org/10.1001/jama.1997.03550010065042
Ferner RE, Gutmann DH. Neurofibromatosis type 1 (NF1): diagnosis and management. Handb Clin Neurol 2015;132:193-214.
Kransdorf MJ, Murphey MD. Imaging of soft tissue tumors. Lippincott Williams & Wilkins 2013.
Rodriguez FJ, Folpe AL, Giannini C, et al. Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol 2012;123(3):295-319. DOI: https://doi.org/10.1007/s00401-012-0954-z
Pilavaki M, Chourmouzi D, Kiziridou A, et al. Imaging of peripheral nerve sheath tumors with pathologic correlation: Pictorial review. Eur J Radiol 2004;52(3):229-39. DOI: https://doi.org/10.1016/j.ejrad.2003.12.001
Wasa J, Nishida Y, Tsukushi S, et al. MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol 2010;194(6):1568-74. DOI: https://doi.org/10.2214/AJR.09.2724
Weiss SW, Goldblum JR. Enzinger and Weiss’s soft tissue tumors. 6th edn. Elsevier 2013.
Fletcher CDM, Bridge JA, Hogendoorn PCW, et al. WHO classification of tumours of soft tissue and bone. 4th edn. IARC Press 2013.
Evans DG, Baser ME, McGaughran J, et al. Malignant peripheral nerve sheath tumors in neurofibromatosis 1. J Med Genet 2002;39(5):311-4. DOI: https://doi.org/10.1136/jmg.39.5.311
Hruban RH, Shiu MH, Senie RT, et al. Malignant peripheral nerve sheath tumors of the buttock and lower extremity: a study of 43 cases. Cancer 1990;66(6):1253-65. DOI: https://doi.org/10.1002/1097-0142(19900915)66:6<1253::AID-CNCR2820660627>3.0.CO;2-R